News Chemistry The smallest known molecular knot is made of just 54 atoms The trefoil knot is also the tightest of its kind In this simplified illustration of the smallest known molecular knot, a chain of 54 gold (red), phosphorus (purple), oxygen (mauve) and carbon (black) atoms crosses itself three times to form a pretzel-like shape. Z. Li et al/Nature Communications 2024 Share this:EmailFacebookTwitterPinterestPocketRedditPrint By Anna Gibbs February 5, 2024 at 8:00 am Imagine a knot so small that it can’t be seen with the naked eye.